ASSESSMENT OF PLATELET INDICES PROFILE OF PREGNANT WOMEN ATTENDING UNIVERSITY OF ABUJA TEACHING HOSPITAL, NIGERIA
Background: Platelets initiate hemostasis by aggregating at the site of injury and plug endothelial defects that usually are a consequence of injuries sustained, in order to prevent further blood loss.
Objective of Study: This case-control study aims to determine the values of platelet counts and platelet indices and the effect in the study participants attending the university of Abuja Teaching Hospital Gwagwalada Abuja, Nigeria.
Materials and Methods: A total of 180 samples were enrolled for the study; this consist of 120 pregnant women as test participants and 60 non-pregnant women as control. Blood samples were collected in EDTA bottle,
and complete platelet count and indices were carried out using an automated five parts haematology analyzer.
Results: The mean±SD platelet count of pregnant women was non-significantly higher than the control subjects (p=0.295). There was decrease but not significant difference in mean±SD platelets volume (MPV), platelets distribution width (PDW) and platelets larger cell ratio (PLCR) of pregnant women than the control subjects (p˃0.05). There was a progressive decline in MPV with gestation age, whereas PDW was higher among pregnant women compared to non-pregnant women. The MPV progressive declined in pregnant women from the 1st to the 3rd trimester (p=0.036).
Conclusion: Platelet count decreases while MPV and PDW increase with the increase in gestation age. These parameters were normal in the non-pregnant controls. It’s recommended to analyze for comprehensive platelet indices of pregnant women with the risk of coagulopathy to promptly and adequately manage associated sequelae.